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Preventing anaplasmosis in cattle 

Preventing anaplasmosis in cattle 

Cattle in a feedlot.

Preston Keres/USDA

With cattle at record values, it is more important than ever to eliminate risk and protect the health of our cattle inventory. Anaplasmosis is a common disease in cattle with worldwide distribution. Accordingly, anaplasmosis will occur every year with some variation of intensity based on the strain of Anaplasma marginale. Anaplasma marginale is a bacteria that infects red blood cells and once an animal becomes infected, they are infected for life.  

Anaplasmosis is transmitted through the bite of ticks and flies, as well as blood-contaminated instruments like needles, tattoo tools, castration equipment and dehorning instruments. This bacteria does not harm the red blood cells directly but the cow’s immune response recognizes it when it reaches certain levels, which then causes anemia due to the immune system killing the red blood cells that are infected. This will limit the amount of oxygen that is transported throughout the animal’s blood, which can then lead to aggressive behaviors exhibited by normally docile cows or bulls.  

Other clinical signs that animals are infected with the bacteria are extreme lethargy, yellowing of the mucous membranes, abortions, weight loss and difficulty breathing. Most producers will not know they have an anaplasmosis problem until they see dead cows or bulls that are older than 2 years of age. This disease can be devastating with death losses in some herds approaching 50%. Fortunately, anaplasmosis can be effectively controlled through several management practices outlined in this article. 

Best management practices  

First, consult with your veterinarian so that they can develop a comprehensive plan to limit the impact of anaplasmosis. This relationship is critically important because the most commonly utilized control plan is to administer tetracycline antibiotics through mineral supplements or feed and the only access to this preventative treatment is to obtain a Veterinary Feed Directive. 

Clinical signs of infections can be treated with injectable antibiotics via an intramuscular injection of oxytetracycline administered multiple days and should be given under a veterinarian’s directions. Successful antibiotic therapy curing the clinical signs of infection results in a carrier animal.  

Carrier cattle will be immune to further disease from anaplasmosis but will remain a source from which needles, flies and ticks can spread the disease. A vaccine is available in some states. This vaccine does not prevent infection, but anecdotal evidence demonstrates a reduction in clinical signs. 

Additional best management practices to prevent and control the transmission of this disease include: 

• Feeding tetracycline antibiotic during the fly and tick seasons (essential). 

• Rotating pastures (when possible) to avoid pastures with a history of tick issues during tick season. 

• Burning pastures in the spring to control ticks. 

• Controlling fly and tick populations to the extent possible. 

• Changing needles and disinfecting any instruments which may result in transmitting blood from animal to animal when working cattle. — Mark Z. Johnson, Oklahoma State University Extension beef cattle breeding specialist 

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1 Comment

  1. yanceybl
    October 2, 2025
    Fed CTC for 30 years. Thanks to AVMA/FDA I now pay a vet to drive through my cattle and say, " Yep, you've got cattle". "Here's your VFD". " That'll be $120".

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